Results of animal experiments on new coronavirus vaccine

Xinhua News Agency, Beijing, May 8 (Reporter Dong Ruifeng) The results of the first animal experimental study of the new coronavirus vaccine have been announced recently, and relevant research articles that have been completed in cooperation with many units including the Institute of Medical Laboratory Animals of the Chinese Academy of Medical Sciences have been published in internationally renowned academic journals "Science" published.

The vaccine that announced the results of animal experiments was developed by Beijing Kexing Zhongwei Biotechnology Co., Ltd. in conjunction with relevant scientific research institutions. On April 13th, it received the clinical trial license of the Phase I and II of the State Drug Administration. One of the new inactivated coronavirus vaccines for research approval.

The published experimental results show that the vaccine can induce the production of new neutralizing virus specific neutralizing antibodies in mice, rats and non-human primates. These antibodies can effectively neutralize many strains from different countries and are representative New strain of coronavirus.

The results of the challenge experiment in rhesus monkeys showed that compared with the control group, the pathological changes of lung tissues of rhesus monkeys after vaccine immunization were significantly reduced, and the viral load was also significantly reduced. The researchers believe that the 6-microgram dose of the candidate vaccine can provide complete protection against the new coronavirus challenge, and the 3-microgram dose of the vaccine has partial protection.

By observing the clinical indicators and biochemical index, the researchers found that the vaccinated rhesus monkeys did not find fever and weight loss, and their appetite and mental state remained normal. The proportion of lymphocyte subsets and key cytokines were compared with the control group. There was no significant change. In addition, the pathological evaluation of various organ tissues showed that the vaccine did not cause significant pathological features. The researchers believe that the above results indicate that the candidate vaccine is safe in rhesus monkeys.

• Up to now, several new coronavirus vaccines have been approved for clinical trials in China. At the press conference of the Joint Defense and Joint Control Mechanism of the State Council, the person in charge of the Ministry of Science and Technology repeatedly emphasized that vaccines are special products for healthy people. Although they are emergency projects, they still emphasize the scientific and procedural nature. Effectiveness is the basic premise.